See this recent study:

 

1: Urologe A. 2003 Dec;42(12):1607-10.

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[Bilateral testicular masses in the scope of adrenogenital syndrome]

[Article in German]

Helke C, May M, Stolz S, Seehafer M, Erler T, Hoschke B.

Klinik fur Urologie, Carl-Thiem-Klinikum, Cottbus. Ch.Helke@ctk.de

Testicular masses in male individuals with the adrenogenital syndrome (AGS) are a clinical and pathological diagnostic dilemma. The major differential diagnosis of gonadal nodules in this setting includes interstitial Leydig cell tumors and secondary benign tumors possibly of adrenal origin. We report a case of adrenogenital syndrome occurring in a 14-year-old boy. Examinations to clarify the cause of his dwarfism and bilateral testicular masses revealed 21-hydroxylase deficiency. The testes were not tender and were firm and nodular on palpation. The serum levels of adrenocorticotrophic hormone (ACTH), 17 alpha-hydroxyprogesterone (17-alpha-OHP), testosterone, and aldosterone were found to be elevated. Under corticosteroid therapy the serum marker abnormalities were corrected and there was gradual regression of the tumor lesions in both testes. Testicular tumors with adrenogenital syndrome are typically bilateral and develop in untreated or inadequately treated males with AGS.

Publication Types:

• Case Reports

PMID: 14668989 [PubMed]

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