i was told originally that each endo has diffferent theories as to when the large dose is necessary - but since then I have found that our friends that also have a daughter that is SW have been told to dose differently from us by the same endos - so now I’m not sure if it has to do more with the patient. . .  we were told to do the large dose at night to mimic a typical body’s production - our friends were told to do the large dose in the morning for the same reason.  Thanks for asking the question I’ve been wondering myself lately.