We give our sons doses @ 4am, 12 noon, and 8pm. My husband gets up @ 4 am to go to work anyway so this works great for us. The endo told us to make sure the doses are never more than 12 hours apart, but I feel better about giving him it every 8 hours.

If you don’t want to stay up so late, may be doing an early morning dose is worth a try. I have given my son alot of early morning doses ( on the weekends) and I just go back to bed for a couple of hours. Our son is only 6 months old and doesn’t wake up when we dose him. I guess we will see what happens when he is older.