Thanks Karen.

Kara - you can find lots of info on circadian dosing in archives.  Basically the theory is that they need the Cortef beginning at about 3:00 AM but if you give it to them at bedtime, it wears off by then.  Also, peak growth is at about midnight.  So if they don’t have the cortef in their system at midnight, it doesn’t suppress growth, and if you wake up and give it to them at 3 AM it may keep the androgens from rising at that time.

I just started it, so I don’t know if it works for us, but other people swear by it.  My son doesn’t seem to be losing any sleep (but I am!).