Yes, we switched to circadian rythmn dosing for weight issues. My now 6 yr old son tended to be oversuppressed, even on a low dose. His height was good, but he gained weight like mad each time we increased his dose (the final straw was 10 lbs in 3 months).

We started circadian dosing in the spring of 2003. His weight is much improved (not losing, but gaining so slowly his height is thinning him out). Getting up at night stinks. I am very glad we made the switch, but would also have to say it was our last resort.