We have had this issue with my daughter.  Her bone age advanced 1 year in 6 months while her levels were right on target.  (Her bone age was already 1 year advanced but that was due to levels that were high as she had growth spurts and increasing meds was hard to keep up.) We were on 4 times per day dosing and now we are on 5 times a day dosing hoping that this will help comver her better.  We did not increase her meds just spread them out more.  If her moods are an indication I’d say it’s working because she is very happy and funny and easy to  get along with where before little things would set her off.  She got a blood draw today....did the switch 6 weeks ago.  WE won’t do another bone age for 4 months so it’s a wait and see.   Good luck,  Julia