Carrie are you the grandmother from New Mexico that I gave my number to a couple of weeks ago? If you are still interested you can call anytime if you need my number again just let me know. As far as med times I give my daughter Elizabeth her prednisone at 8am along with her sodium chloride and florineff. I give her another dose of sodium chloride at 2pm and her steroid, sodium chloride and florineff again around 8pm. I have heard of children getting their meds at all different times. You might want to have you daughter talk to her endo about how many hours apart the doses need to be and that would help you out from there on. If she has a set amount of hours between the doses I would think 11pm would be okay as long as there is an appropriate time between the first and last dose of the day.Dana