Crystal,

I have an article here of a Finnish study (Tiitine & Valimaki) published in 2002 entitled: Primary Infertility in 45 Year-Old Man with Untreated 21-Hydroxylase Deficiency: Successful Outcome with Glucocorticoid Therapy.

This paper outlines the history of a 45 year old man who presents with infertility of two years duration. Extensive testing was done and he was diagnosed with CAH eg. 17-OHP 978 nmol/L (32,500ng/dL). This man was commenced on corticosteroid medication and within five months, apart from his adrenal androgen levels improving dramatically, so had his sperm count. His wife became pregnant soon after.

The summary of this article was: "Undiagnosed and or/untreated 21-hydroxylase deficiency may underlie male infertility due to the suppression of gonadotrophin secretion. Our patient shows that even after a long duration of gonadotrophin deficiency fertility can be achieved with appropriate treatment with glucocorticoids."