We hear ya on the highs and lows from treatment.  This is why we give the meds 5 times a day.  It’s really not that hard at all.  Just with all 3 meals, at 10pm and 3am.  We feel this is doing the absolute best we can for our daughter.  Before she was on a higher per meter squared dose and wasn’t growing at all, huge puffy, red cheeks and she would not sleep.  Now all is much better and these oversuppression signs are gone.  If only they would make a timed release capsule......dream on!  Julia