I’ve been doing circadian dosing for about 6 months.  I do three equal doses at 3 am, 7:30 am, and 3:30 - 5:30 P.M. (I try to do it at 3:30 but forget alot!).  To avoid the problem of too long a period overnight without meds, would it be better to do it at 5:30 P.M. and 2:00 AM?