re: re: re: Question for those who stopped prenatal treatment early and gave birth to an affected girl...
Jun. 15th, 2005   9:22pm

Hi Risty,

i just wanted to share what i know with you. I am taking Dex right now and doing some research on it. you are right, i am not from the US but i live in here so all the information i got is from the journals and doctors here. i don’t know about the procedures in other countries.

anyway, i have a study about dex and i am coping a paragraph from it along with the citation. please share your thoughts about the finding. i can send you the whole study in pdf format.

Long-Term Somatic Follow-Up of Prenatally Treated

Children with Congenital Adrenal Hyperplasia*

SVETLANA LAJIC, ANNA WEDELL, THE-HUNG BUI, E. MARTIN RITZE´ N, AND

MIKAEL HOLST

Journal of Clinical Endocrinology and Metabolism (1998)

 Vol. 83, No. 11

 

Prenatal treatment of 21OHD with DEX was effective in

preventing virilization of external genitalia in affected females,

provided that treatment was begun before the seventh

week of gestation and was continued without interruption

until term. One affected female in our study was not treated

in an optimal fashion due to poor maternal compliance. This

girl was born more virilized (Prader stage 2–3) than her older

sister, who had normal external genitalia, but was less virilized

than her untreated sister (Prader stage 4). Similar observations

have been reported from other studies where

treatment was started around the 10th week of gestation and

was interrupted during the late second or early third trimester

of pregnancy (19, 26). These findings clearly demonstrate

the importance of early initiation and continuation of

treatment until term. It is also crucial that the mother is

carefully informed about possible maternal side-effects and

provided with support and follow-up during the treatment.

 

Mio
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