Our daughter with swcah had her medicine changed, not just the dose but the medicine as well. We defintely noticed that she has been more emotional, moody and grumpy. We have been wondering the same thing. Maybe it takes them awhile to adjust to the change? It can be frustrating though that many doctors will not relate anything emotional to their cah. If they only had a child of their own with cah they would see what we see. Hope this helps. How old is your daughter?