When I get up in the morning and put my contacts in, I take my medicine, no matter if it is 5AM, 6AM, or 8AM.  At that point I also put out pills for the afternoon and evening.  When I get home from work I take the afternoon and when I go to bed I take the evening ones, even if the times change by an hour or two a day.   

I have found that for myself it is easier to remember that I have taken my pills this way since I can see them sitting out on my counter and know that I have not taken them yet.