Thanks Tonia!!  Do their grandparents get up 2:00A.M. and give them their meds or do the girls get up from their own wrist watch alarm?  Do they ever spend the night at a friend’s house?  How do they get their meds then?  I have a 16yr old girl and a 10yr old boy.  For starters, I’m going to get up at 3:30A.M., but soon I’ll have my 16yr old start setting her own alarm.  Thanks so much for your advice!!