AIS is kinda like CAH- you have both males and females affected by the condition. However, with females with AIS, it doesn’t matter if you have faulty androgen receptors: you’re more concerned about estrogen production than androgen production (just like if you’re a baby boy with CAH you don’t have to worry about excess androgens!)
I think that females with AIS usually go undiagnosed- there’s nothing really wrong with them, after all. However, in the case with these families there was a known history of CAH as well as the AIS. So when these girls were born with CAH but had unvirilized genitalia, they discovered they also had AIS.
Reading about a case like this, tho, makes me wonder if anyone has looked into treating women who are carrying girls affected with CAH with something block the androgen receptors. I would think it might be easier for the mother to use something like that than stay on dex tho whole pregnancy. However, you’d have to be 100% sure that it was a girl- androgen receptor blockers would be really bad for boys!
I hope this made sense- I feel as if I’m rambling today--

Martha