Why is it then that generally people with dex put on huge amounts of weight, have stretch marks, and a lot more side effects.  Pred also affects some terribly - the answer really is simple, right dose given throughout the day and a good sensible diet with exercise. ALL steroids cause weight gain if not given in the right dose and this overtime leads to all these other problems.... in my mind hydro is the closest natural substitute to cortisol and we have seen by many from giving it to mimic the circadian dosing weight issues are less and better growth.