We do three times.  Upon getting up in the morning, when he gets home from school or at about 3:30 in the afternoon and at 3 AM.  He has a mild case.  I think some people dose 4 times or even 5 times.  The key to the whole thing is that they don’t need cortef in the evening and they grow at about midnight so if you dose them before bed, they’re taking medication they don’t need and it inteferes with their growth.  They need it from about 3 AM through the morning.  If you dose before bed then it wears off by 3 AM.  So with the circadian dosing you can usually get better treatment with less drugs.