Thanks so much Beth D, Louise, Sherry.

Beth D, you are totally right. Lab test is key drive.

Louise, your thought made sense to me. I feel warm with your advice.  

Sherry, thanks so much for your experience sharing. Three months ago, my daughter first dose is at 4:30AM also, and her 17OHP is rather low.  I tried to adjust to 3:30AM just to match with the principle that cortisone level start to rise at 2AM-3AM. Can you please share with me the medication timing for your child? I will learn something from that. Thanks a lot.