We have move around alot and as a result had to change doctors.  Up until we found our last endo we were told that it didn’t matter what time the medication was given.  We even had a doctor tell us once that we could let our son sleep in till 10am and give him his meds when a woke.  I could never in good conscience to this.  For the first 10 years we dosed at 6am, 3-4pm and bedtime.  By the time my son was 6 years old his bone age had advanced 5 years.  Still no one recommended changing the doseage schedule.  It’s frustrating, because we have doctored with the department heads at Children’s Hospital.  When we moved 3 years ago, we were really struggling with the labs,  I’m thinking his 17OHP was up to 3500 at one point and he was taking 35 mg of Cortef a day.  His new endo cut his dosage in half and changed the doseage times.  He prescribed 7.5mg @ 4:30-5:00 am, 5mg @ 3-4pm and 5mg @ bedtime.  His labs came back perfect!!!  He has done very well on this schedule and has started slimming down and growing.

I have asked our doctor about the circadium dosing.  He says that kids need suppression approximately 1 hour before they wake.  He feels as though the Cortef will not suppress effectively if given at 3:00am as it will be out of their system before their body needs it.  I know there are alot of people who feel differently  on this subject.  All I know is that this is really working for my son.

I hope this helps.