When the endo changed my Florinef, I experienced a rapid weight loss.(40-50 lbs. in about 4-5 mos.)  My blood pressure also decreased.  I had been prescribed high blood pressure meds. when I was 20.  I was not religious about taking them because I worried about it interfering with my CAH and med levels.  That’s when my endo reduced the Florinef and Cortef, and I haven’t had a problem with my blood pressure since!  It is actually a little lower than the average for my age of 28.