Thru some trial and error-  my SW CAH boys are 7 and 10-  I have founde that I dose the kids at bedtime (I am talking about when they are sick)  double or triple depending on how sick and give motrin-  then I set my alarm and dose 6-7 hours later with cortef, motrin and a sweet drink.

I am not a worrier and I never used to wake my kids up,  but a couple of times my kids have waken up (or rather I had to wake them up) in pretty bad shape- anyway that is what I do now and it seems to work.  My kids dont seem to get sick as often as they have gotten older. 

Good luck.

It does get easier!