This is interesting. The only thought I have is that because dosing this way is more effective, possibly in time the meds could be reduced. It might be the cause of sleeplessness and weight gain. What percentages of daily dose is she getting at what times? The largest doses should be the 3am and 7am with them getting smaller at noon and 5:30. Good luck. My daughter is on this dosing ans has been for at least 4 years with GREAT success: better sleeping, no moon face, started growing and has stayed at the same percentile! I hope this works. Julia