Hi Amy,

I take my prednisone almost exactly as you take yours (same dose). I find this way mimics circadian rhythm pretty closely.   What I will say is that if i miss my bedtime dose, I’m pretty much out for the count for the next day--regardless if I take (or even double) the morning dose at 6:30am. However, I have SWCAH so this might factor more into my fatigue than NCAH would.

This is really something you should discuss with your physician as well as weigh against how you feel.  Prednison is most often given in 2 doses. My only concern with once a day dosing is that while you may feel perfectly fine, your levels may get out of control with no coverage into the late afternoon/late evening.

Good luck,

Erin