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re: Good News--Also on Main Board. Oct. 29th, 2007 1:38pm
Aromatase inhibitors help slow down bone aging by preventing the conversion of testosterone into estrone, estrone being the hormone responsible for bone closure. This could result in a higher testosterone level. No one minds (much) for growing boys, it's acceptable as long as the drug prevents short stature and baldness. For growing girls, it might be advisable to watch her testosterone levels very carefully. Androgens in girls are less accepted.
For girls entering puberty, some aromatization is required for estrogen production in the ovaries. Complete inhibition may hinder normal cycles -(?)
If (and only if) your daughter's cortef dose goes far beyond her actual cortisol-replacement needs for the sake of suppressing her androgens -- it may be possible to use a smaller cortef dose, in conjunction with a 17-alpha-hydroxylase inhibitor such as ketoconazole to inhibit her androgen production. Excessive cortisol has been known to cause many of the emotional/psychological side-effects you describe.
Caveat: these are only ideas for discussion with your chosen endocrinologist, with no intention expressed or implied that this should be interpeted as applicable medical advice.
