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Has anyone else here had this side effect? I am currently on 5 mg Prednisone a day & 50 mg Spironolacto twice a day. I called my endos office friday & they said to double my Spiro & if hadn't gone away by monday to call them back. Well it has gotten less severe, but still exists. It is not in my thighs or feet, just my calves. I noticed it when my sweat pants left about an inch deep indent when I woke up. Creepy!!