Authors: Martinez-Aguayo A. Rocha A. Rojas N. Garcia C. Parra R. Lagos M. Valdivia L. Poggi H. Cattani A. Chilean Collaborative Testicular Adrenal Rest Tumor Study Group.

Institution: Endocrinology Unit, Department of Pediatrics, Pontificia UniversidadCatolica de Chile, 833-0074, Santiago, Chile. alemarti@med.puc.cl

Title: Testicular adrenal rest tumors and Leydig and Sertoli cell function inboys with classical congenital adrenal hyperplasia.

Source: Journal of Clinical Endocrinology & Metabolism. 92(12):4583-9, 2007 Dec.

Abstract

CONTEXT: Infertility observed in adult males with congenital adrenal hyperplasia (CAH) has been associated with testicular adrenal rest tumors (TART) that may originate during childhood.

OBJECTIVE: Our objective was to describe the prevalence of TART and Sertoli and Leydig cell function in a group of boys aged 2-1 0 yr with CAH and to compare prevalence with that of a control group.

DESIGN: From August 2005 to January 2007, 19 patients with classical CAH (CAH group) were referred from seven endocrinology centers.

METHODS: We studied 19 subjects in the CAH group and, as a control group, 13 boys from the community that did not have testicular diseases. A complete physical exam was performed. High-resolution ultrasound was used to determine TART prevalence. Inhibin B and anti-Mullerian hormone were used as Sertoli cell markers. The ratio between basal testosterone levels and testosterone levels 72 h after beta-human chorionic gonadotropin (5000 U/m2) treatment [(T72- T0)/T0] was used to evaluate Leydig cell response.

RESULTS: CAH and control groups were comparable in chronological age (5.9 vs. 5.6 yr; P = 0.67) and bone age/chronological age ratio (1.09 vs. 1.03; P = 0.09). TART prevalence was four of 19 (21%) in the CAH group. Lower values for inhibin B (49.2. vs. 65.2 pg/ml; P = 0.018), anti-Mullerian hormone (70.1 vs. 94.2 ng/ml; P = 0.002), and (T72- T0)/T0 (5.6 vs. 13.6; P < 0.01) were observed in the CAH group.

CONCLUSION: TART in prepubertal males with classic CAH could be found during childhood. We also report differences in markers of gonadal function in a subgroup of patients, especially in those with inadequate control.